abstract：BACKGROUND:Tobacco smoke exposure may be associated with increased breast cancer risk, although the evidence supporting the association is inconclusive. We conducted a case-control study in Delaware, incorporating detailed exposure assessment for active and secondhand smoke at home and in the workplace. METHODS:Primar...

journal_title：BMC cancer

authors： Rollison DE,Brownson RC,Hathcock HL,Newschaffer CJ

更新日期：2008-06-02 00:00:00

abstract：BACKGROUND:Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G), as well as the matched ascites for one case (OV-1946). METHODS:In addition to growth parameters,...

journal_title：BMC cancer

authors： Ouellet V,Zietarska M,Portelance L,Lafontaine J,Madore J,Puiffe ML,Arcand SL,Shen Z,Hébert J,Tonin PN,Provencher DM,Mes-Masson AM

更新日期：2008-05-28 00:00:00

abstract：BACKGROUND:The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases...

journal_title：BMC cancer

authors： Henkens R,Delvenne P,Arafa M,Moutschen M,Zeddou M,Tautz L,Boniver J,Mustelin T,Rahmouni S

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as first-line palliative combination chemotherapy. We also analyzed the predictive or prognostic value of...

journal_title：BMC cancer

authors： Keam B,Im SA,Han SW,Ham HS,Kim MA,Oh DY,Lee SH,Kim JH,Kim DW,Kim TY,Heo DS,Kim WH,Bang YJ

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:Cancer stem cell (CSC) hypothesis has not been well demonstrated by the lack of the most convincing evidence concerning a single cell capable of giving rise to a tumor. The scarcity in quantity and improper approaches for isolation and purification of CSCs have become the major obstacles for great developmen...

journal_title：BMC cancer

authors： Li HZ,Yi TB,Wu ZY

更新日期：2008-05-14 00:00:00

abstract：BACKGROUND:Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in human pancreatic carcinomas. METHODS:In this study, we established a MBD1-knock-down pancreatic cancer ...

journal_title：BMC cancer

authors： Liu C,Chen Y,Yu X,Jin C,Xu J,Long J,Ni Q,Fu D,Jin H,Bai C

更新日期：2008-04-29 00:00:00

abstract：BACKGROUND:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. Th...

journal_title：BMC cancer

authors： Ye F,Zhou C,Cheng Q,Shen J,Chen H

更新日期：2008-04-18 00:00:00

abstract：PURPOSE:Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practitioners is not well known. METHODS:Two nationwide observational telephone surveys were conducted in early ...

journal_title：BMC cancer

authors： Eisinger F,Cals L,Calazel-Benque A,Blay JY,Coscas Y,Dolbeault S,Namer M,Pivot X,Rixe O,Serin D,Roussel C,Morère JF,EDIFICE committee.

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed ...

journal_title：BMC cancer

authors： Batista LI,Lu KH,Beahm EK,Arun BK,Bodurka DC,Meric-Bernstam F

更新日期：2008-04-14 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based compara...

journal_title：BMC cancer

authors： Carneiro A,Isinger A,Karlsson A,Johansson J,Jönsson G,Bendahl PO,Falkenback D,Halvarsson B,Nilbert M

更新日期：2008-04-11 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...

journal_title：BMC cancer

authors： Kilpivaara O,Rantanen M,Tamminen A,Aittomäki K,Blomqvist C,Nevanlinna H

更新日期：2008-03-10 00:00:00

abstract：BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...

journal_title：BMC cancer

authors： Mikhitarian K,Martin RH,Ruppel MB,Gillanders WE,Hoda R,Schutte del H,Callahan K,Mitas M,Cole DJ

更新日期：2008-02-20 00:00:00

abstract：BACKGROUND:FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been reported in a variety of human tumour entities. FOXM1 is a gene of interest because recently chemical in...

journal_title：BMC cancer

authors： Bektas N,Haaf At,Veeck J,Wild PJ,Lüscher-Firzlaff J,Hartmann A,Knüchel R,Dahl E

更新日期：2008-02-06 00:00:00

abstract：BACKGROUND:Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive. METHODS:We developed a pathway based classifier approach to predict pr...

journal_title：BMC cancer

authors： Herbsleb M,Christensen OF,Thykjaer T,Wiuf C,Borre M,Orntoft TF,Dyrskjøt L

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT. METHODS:Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patie...

journal_title：BMC cancer

authors： Quero L,Mongiat-Artus P,Ravery V,Maylin C,Desgrandchamps F,Hennequin C

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:Genetically engineered mouse models of mammary gland cancer enable the in vivo study of molecular mechanisms and signaling during development and cancer pathophysiology. However, traditional whole mount and histological imaging modalities are only applicable to non-viable tissue. METHODS:We evaluated three ...

journal_title：BMC cancer

authors： Tilli MT,Parrish AR,Cotarla I,Jones LP,Johnson MD,Furth PA

更新日期：2008-01-23 00:00:00

abstract：BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...

journal_title：BMC cancer

authors： Jiang Q,Wei H,Tian Z

更新日期：2008-01-17 00:00:00

abstract：BACKGROUND:The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts surviva...

journal_title：BMC cancer

authors： Westgaard A,Tafjord S,Farstad IN,Cvancarova M,Eide TJ,Mathisen O,Clausen OP,Gladhaug IP

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...

journal_title：BMC cancer

authors： Zhang XH,Huang DP,Guo GL,Chen GR,Zhang HX,Wan L,Chen SY

更新日期：2008-01-13 00:00:00

abstract：BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...

journal_title：BMC cancer

authors： Stücker I,Loriot MA,N'koutchou G,Cénée S,Bodin L,Mulot C,Gelu-Simeon M,Pelletier L,Bronowicki JP,Degos F,Beaune P,Laurent-Puig P,Hémon D,Trinchet JC,Pelletier G

更新日期：2007-11-19 00:00:00

abstract：BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...

journal_title：BMC cancer

authors： Saban MR,Hellmich HL,Simpson C,Davis CA,Lang ML,Ihnat MA,O'Donnell MA,Wu XR,Saban R

更新日期：2007-11-02 00:00:00

abstract：BACKGROUND:The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether th...

journal_title：BMC cancer

authors： Liu C,Lu P,Lu Y,Xu H,Wang S,Chen J

更新日期：2007-10-24 00:00:00

abstract：BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...

journal_title：BMC cancer

authors： Ordás J,Millán Y,Dios R,Reymundo C,de Las Mulas JM

更新日期：2007-09-20 00:00:00

abstract：BACKGROUND:The present study evaluates the outcome of 19 children with rhabdomyosarcoma of the head-and-neck region treated with Intensity Modulated Radiotherapy (IMRT) or Fractionated Stereotactic Radiotherapy (FSRT) between August 1995 and November 2005. METHODS:We treated 19 children with head-and-neck rhabdomyosar...

journal_title：BMC cancer

authors： Combs SE,Behnisch W,Kulozik AE,Huber PE,Debus J,Schulz-Ertner D

更新日期：2007-09-13 00:00:00

abstract：BACKGROUND:Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophag...

journal_title：BMC cancer

authors： Bacman D,Merkel S,Croner R,Papadopoulos T,Brueckl W,Dimmler A

更新日期：2007-08-10 00:00:00

abstract：BACKGROUND:The use of combined positron emission tomography/computerised tomography (PET/CT) scanners in oncology has been shown to improve the staging of tumours and the detection of relapses. However, mis-registration errors are increasingly recognised to be a common pitfall of PET/CT studies. CASE PRESENTATION:We r...

journal_title：BMC cancer

authors： Wang J,Cook G,Frank J,Dina R,Livni N,Lynn J,Fleming W,Seckl MJ

更新日期：2007-08-03 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia a...

journal_title：BMC cancer

authors： Schilling D,Bayer C,Geurts-Moespot A,Sweep FC,Pruschy M,Mengele K,Sprague LD,Molls M

更新日期：2007-07-30 00:00:00

abstract：BACKGROUND:Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and par...

journal_title：BMC cancer

authors： Haffner MC,Petridou B,Peyrat JP,Révillion F,Müller-Holzner E,Daxenbichler G,Marth C,Doppler W

更新日期：2007-07-25 00:00:00

abstract：BACKGROUND:The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid instrument measuring satisfaction among patients with breast cancer and exploring their care itiner...

journal_title：BMC cancer

authors： Defossez G,Mathoulin-Pelissier S,Ingrand I,Gasquet I,Sifer-Riviere L,Ingrand P,Salamon R,Migeot V,REPERES research network.

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist...

journal_title：BMC cancer

authors： Huang J,Zhang YL,Teng XM,Lin Y,Zheng DL,Yang PY,Han ZG

更新日期：2007-07-12 00:00:00

abstract：BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...

journal_title：BMC cancer

authors： Fan C,Jin M,Chen K,Zhang Y,Zhang S,Liu B

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. METHODS:Taiwan Cancer Registry records of 9039 subjects diagnos...

journal_title：BMC cancer

authors： Chen PH,Shieh TY,Ho PS,Tsai CC,Yang YH,Lin YC,Ko MS,Tsai PC,Chiang SL,Tu HP,Ko YC

更新日期：2007-06-15 00:00:00

abstract：BACKGROUND:cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and pro...

journal_title：BMC cancer

authors： Figueiredo JC,Knight JA,Cho S,Savas S,Onay UV,Briollais L,Goodwin PJ,McLaughlin JR,Andrulis IL,Ozcelik H

更新日期：2007-06-14 00:00:00

abstract：BACKGROUND:Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with clinically different phenotypes. However, such data is still rare for important patient subgroups, s...

journal_title：BMC cancer

authors： Warnat P,Oberthuer A,Fischer M,Westermann F,Eils R,Brors B

更新日期：2007-05-25 00:00:00

abstract：BACKGROUND:The high complication rates of surgically implanted port catheter systems (SIPCS) represents a major drawback in the treatment of isolated liver neoplasms by hepatic arterial infusion (HAI) of chemotherapy. Interventionally implanted port catheter systems (IIPCS) have evolved into a promising alternative tha...

journal_title：BMC cancer

authors： Hildebrandt B,Pech M,Nicolaou A,Langrehr JM,Kurcz J,Bartels B,Miersch A,Felix R,Neuhaus P,Riess H,Dörken B,Ricke J

更新日期：2007-04-24 00:00:00

abstract：BACKGROUND:The mammalian FOXO (forkhead box, O subclass) proteins are a family of pleiotropic transcription factors involved in the regulation of a broad range of cellular processes critical for survival. Despite the essential and diverse roles of the FOXO family members in human cells and their involvement in tumor pa...

journal_title：BMC cancer

authors： Dallas PB,Egli S,Terry PA,Kees UR

更新日期：2007-04-19 00:00:00

abstract：BACKGROUND:The sex hormone-binding globulin (SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of ...

journal_title：BMC cancer

authors： Garcia-Closas M,Brinton LA,Lissowska J,Richesson D,Sherman ME,Szeszenia-Dabrowska N,Peplonska B,Welch R,Yeager M,Zatonski W,Chanock SJ

更新日期：2007-04-05 00:00:00

abstract：BACKGROUND:Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. METHODS:Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and B...

journal_title：BMC cancer

authors： Zhou Y,Yau C,Gray JW,Chew K,Dairkee SH,Moore DH,Eppenberger U,Eppenberger-Castori S,Benz CC

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...

journal_title：BMC cancer

authors： Elkiran ET,Mar N,Aygen B,Gursu F,Karaoglu A,Koca S

更新日期：2007-03-15 00:00:00